Knoxville is a city in the U.S. state of Tennessee, and the county seat of Knox County. The city had an estimated population of 185,291 in 2015 and a population of 178,874 as of the 2010 census, making it the state's third largest city after Nashville and Memphis. Knoxville is the principal city of the Knoxville Metropolitan Statistical Area, which, in 2013, had an estimated population of 852,715.

Knoxville is the home of the flagship campus of the University of Tennessee, whose sports teams, called the "Volunteers" or "Vols," are extremely popular in the surrounding area. Knoxville is also home to the headquarters of the Tennessee Valley Authority, the Tennessee Supreme Court's courthouse for East Tennessee, and the corporate headquarters of several national and regional companies. As one of the largest cities in the Appalachian region, Knoxville has positioned itself in recent years as a repository of Appalachian culture, and is one of the gateways to the Great Smoky Mountains National Park.